KMID : 0882420080740020198
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Korean Journal of Medicine 2008 Volume.74 No. 2 p.198 ~ p.202
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A case of leptomeningeal metastasis from adenocarcinoma of the lung improved by treatment with Gefitinib
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Yu Sung-Ken
Park Won-Jong Chung Jin-Hong Lee Kwan-Ho Shin Kyeong-Cheol Park Chan-Seo Chin Hyun-Jung
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Abstract
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Leptomeningeal metastasis occurs in approximately 1% of patients with non-small cell lung cancer and this is an extremely serious complication. Without treatment, the median survival of patients is 4~6 weeks. The treatment options currently available are limited and achieve only modest results. Gefitinib was recently approved for the teatment of advanced/refractory non-small cell lung cancer. In addition, there have been case reports showing activity of gefitinib against brain metastasis in non-small cell lung cancer patients. However, there is limited data on the ability of gefitinib to cross the blood-brain barrier. We report the case of a patient with leptomeningeal metastasis from adenocarcinoma of the lung that had a dramatic response to gefitinib treatment.
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KEYWORD
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Leptomeningeal metastasis, Non-small cell lung cancer, Gefitinib
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